gabriel amine synthesis
The alkylation of phthalimide with alkyl halides was first reported in 1884 but in 1887 S. Siegmund Gabriel 18511924 born in Berlin Germany studied under Hofmann at Berlin and Bunsen in Heidelberg. Basicity Of Disubstituted Aromatic Amines Resonance Mesomeric Effect Organic Chemistry Chemistry Pi Bond This reaction was identified by Siegmund Gabriel. . To make things clear the question was a multistep synthesis that required me to put a structure in a blank box. Alternatively the workup may be via the IngManske procedure involving reaction with hydrazine. The Gabriel Phthalimide Synthesis reaction is used to produce primary amines from primary alkyl halides. In the following practice problems the reactions and different ways of preparing amines will be discussed. Since hindered amines are not generated by Gabriels Phthalimide synthesis the amine should not be hindered. First up the Gabriel synthesis of primary amines. ...